[Code of Federal Regulations]

[Title 21, Volume 6]

[Revised as of April 1, 2018]

[CITE: 21CFR582.20]

 

TITLE 21--FOOD AND DRUGS

CHAPTER I--FOOD AND DRUG ADMINISTRATION
DEPARTMENT OF HEALTH AND HUMAN SERVICES

SUBCHAPTER E--ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS

PART 582 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE

Subpart A--General Provisions

Sec. 582.20 Essential oils, oleoresins (solvent-free), and natural extractives (including distillates).

Essential oils, oleoresins (solvent-free), and natural extractives (including distillates) that are generally recognized as safe for their intended use, within the meaning of section 409 of the act, are as follows:

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Common nameBotanical name of plant source

AlfalfaMedicago sativa L.

AllspicePimenta officinalis Lindl.

Almond, bitter (free from prussic acid)Prunus amygdalus Batsch, Prunus armeniaca L. or Prunus persica (L.) Batsch.

Ambrette (seed)Hibiscus moschatus Moench.

Angelica rootAngelica archangelica L.

Angelica seedDo.

Angelica stemDo.

Angostura (cusparia bark)Galipea officinalis Hancock.

AnisePimpinella anisum L.

AsafetidaFerula assa-foetida L. and related spp. of Ferula.

Balm (lemon balm)Melissa officinalis L.

Balsam of PeruMyroxylon pereirae Klotzsch.

BasilOcimum basilicum L.

Bay leavesLaurus nobilis L.

Bay (myrcia oil)Pimenta racemosa (Mill.) J. W. Moore.

Bergamot (bergamot orange)Citrus aurantium L. subsp. bergamia Wright et Arn.

Bitter almond (free from prussic acid)Prunus amygdalus Batsch, Prunus armeniaca L., or Prunus persica (L.) Batsch.

Bois de roseAniba rosaeodora Ducke.

CacaoTheobroma cacao L.

Camomile (chamomile) flowers, HungarianMatricaria chamomilla L.

Camomile (chamomile) flowers, Roman or EnglishAnthemis nobilis L.

CanangaCananga odorata Hook. f. and Thoms.

CapsicumCapsicum frutescens L. and Capsicum annuum L.

CarawayCarum carvi L.

Cardamom seed (cardamon)Elettaria cardamomum Maton.

Carob beanCeratonia siliqua L.

CarrotDaucus carota L.

Cascarilla barkCroton eluteria Benn.

Cassia bark, ChineseCinnamomum cassia Blume.

Cassia bark, Padang or BataviaCinnamomum burmanni Blume.

Cassia bark, SaigonCinnamomum loureirii Nees.

Celery seedApium graveolens L.

Cherry, wild, barkPrunus serotina Ehrh.

ChervilAnthriscus cerefolium (L.) Hoffm.

ChicoryCichorium intybus L.

Cinnamon bark, CeylonCinnamomum zeylanicum Nees.

Cinnamon bark, ChineseCinnamomum cassia Blume.

Cinnamon bark, SaigonCinnamomum loureirii Nees.

Cinnamon leaf, CeylonCinnamomum zeylanicum Nees.

Cinnamon leaf, ChineseCinnamomum cassia Blume.

Cinnamon leaf, SaigonCinnamomum loureirii Nees.

CitronellaCymbopogon nardus Rendle.

Citrus peelsCitrus spp.

Clary (clary sage)Salvia sclarea L.

Clove budEugenia caryophyllata Thunb.

Clove leafDo.

Clove stemDo.

CloverTrifolium spp.

Coca (decocainized)Erythroxylum coca Lam. and other spp. of Erythroxylum.

CoffeeCoffea spp.

Cola nutCola acuminata Schott and Endl., and other spp. of Cola.

CorianderCoriandrum sativum L.

Corn silkZea mays L.

Cumin (cummin)Cuminum cyminum L.

Curacao orange peel (orange, bitter peel)Citrus aurantium L.

Cusparia barkGalipea officinalis Hancock.

DandelionTaraxacum officinale Weber and T. laevigatum DC.

Dandelion rootDo.

DillAnethum graveolens L.

Dog grass (quackgrass, triticum)Agropyron repens (L.) Beauv.

Elder flowersSambucus canadensis L. and S. nigra L.

Estragole (esdragol, esdragon, tarragon)Artemisia dracunculus L.

Estragon (tarragon)Do.

Fennel, sweetFoeniculum vulgare Mill.

FenugreekTrigonella foenum-graecum L.

Galanga (galangal)Alpinia officinarum Hance.

GarlicAllium sativum L.

GeraniumPelargonium spp.

Geranium, East IndianCymbopogon martini Stapf.

Geranium, rosePelargonium graveolens L'Her.

GingerZingiber officinale Rosc.

GlycyrrhizaGlycyrrhiza glabra L. and other spp. of Glycyrrhiza.

Glycyrrhizin, ammoniatedDo.

GrapefruitCitrus paradisi Macf.

GuavaPsidium spp.

Hickory barkCarya spp.

Horehound (hoarhound)Marrubium vulgare L.

HopsHumulus lupulus L.

HorsemintMonarda punctata L.

HyssopHyssopus officinalis L.

ImmortelleHelichrysum augustifolium DC.

JasmineJaminum officinale L. and other spp. of Jasminum.

Juniper (berries)Juniperus communis L.

Kola nutCola acuminata Schott and Endl., and other spp. of Cola.

Laurel berriesLaurus nobilis L.

Laurel leavesLaurus spp.

LavenderLavandula officinalis Chaix.

Lavender, spikeLavandula latifolia Vill.

LavandinHybrids between Lavandula officinalis Chaix and Lavandula latifolin Vill.

LemonCitrus limon (L.) Burm. f.

Lemon balm (see balm).

Lemon grassCymbopogon citratus DC. and Cymbopogon flexuosus Stapf.

Lemon peelCitrus limon (L.) Burm. f.

LicoriceGlycyrrhiza glabra L. and other spp. of Glycyrrhiza.

LimeCitrus aurantifolia Swingle.

Linden flowersTilia spp.

Locust beanCeratonia siliqua L.

LupulinHumulus lupulus L.

MaceMyristica fragrans Houtt.

Malt (extract)Hordeum vulgare L., or other grains.

MandarinCitrus reticulata Blanco.

Marjoram, sweetMajorana hortensis Moench.

Mate 1Ilex paraguariensis St. Hil.

Melissa (see balm).

MentholMentha spp.

Menthyl acetateDo.

Molasses (extract)Saccharum officinarum L.

MustardBrassica spp.

NaringinCitrus paradisi Macf.

Neroli, bigaradeCitrus aurantium L.

NutmegMyristica fragrans Houtt.

OnionAllium cepa L.

Orange, bitter, flowersCitrus aurantium L.

Orange, bitter, peelDo.

Orange leafCitrus sinensis (L.) Osbeck.

Orange, sweetDo.

Orange, sweet, flowersDo.

Orange, sweet, peelDo.

OriganumOriganum spp.

PalmarosaCymbopogon martini Stapf.

PaprikaCapsicum annuum L.

ParsleyPetroselinum crispum (Mill.) Mansf.

Pepper, blackPiper nigrum L.

Pepper, whitePiper nigrum L.

PeppermintMentha piperita L.

Peruvian balsamMyroxylon pereirae Klotzsch.

PetitgrainCitrus aurantium L.

Petitgrain lemonCitrus limon (L.) Burm. f.

Petitgrain mandarin or tangerineCitrus reticulata Blanco.

PimentaPimenta officinalis Lindl.

Pimenta leafPrimenta officinalis Lindl.

Pipsissewa leavesChimaphila umbellata Nutt.

PomegranatePunica granatum L.

Prickly ash barkXanthoxylum (or Zanthoxylum) Americanum Mill. or Xanthoxylum clava-herculis L.

Rose absoluteRosa alba L., Rosa centifolia L., Rosa damascena Mill., Rosa gallica L., and vars. of these spp.

Rose (otto of roses, attar of roses)Do.

Rose budsDo.

Rose flowersDo.

Rose fruit (hips)Do.

Rose geraniumPelargonium graveolens L'Her.

Rose leavesRosa spp.

RosemaryRosmarinus officinalis L.

RueRuta graveolens L.

SaffronCrocus sativus L.

SageSalvia officinalis L.

Sage, GreekSalvia triloba L.

Sage, SpanishSalvia lavandulaefolia Vahl.

St. John's breadCeratonia siliqua L.

Savory, summerSatureia hortensis L.

Savory, winterSatureia montana L.

Schinus molleSchinus molle L.

Sloe berries (blackthorn berries)Prunus spinosa L.

SpearmintMentha spicata L.

Spike lavenderLavandula latifolia Vill.

TamarindTamarindus indica L.

TangerineCitrus reticulata Blanco.

Tannic acidNutgalls of Quercus infectoria Oliver and related spp. of Quercus. Also in many other plants.

TarragonArtemisia dracunculus L.

TeaThea sinensis L.

ThymeThymus vulgaris L. and Thymus zygis var. gracilis Boiss.

Thyme, whiteDo.

Thyme, wild or creepingThymus serpyllum L.

Triticum (see dog grass).

TuberosePolianthes tuberosa L.

TurmericCurcuma longa L.

VanillaVanilla planifolia Andr. or Vanilla tahitensis J. W. Moore.

Violet flowersViola odorata L.

Violet leavesDo.

Violet leaves absoluteDo.

Wild cherry barkPrunus serotina Ehrh.

Ylang-ylangCananga odorata Hook. f. and Thoms.

Zedoary barkCurcuma zedoaria Rosc.